Knoepfelmacher Mirta, Danilovic Debora L S, Rosa Nasser Rubia H R, Mendonça Berenice B
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Fertil Steril. 2006 Sep;86(3):719.e15-8. doi: 10.1016/j.fertnstert.2006.01.055.
To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.
Case report.
Outpatient practice.
PATIENT(S): Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels.
INTERVENTION(S): Cabergoline treatment and transsphenoidal surgery.
MAIN OUTCOME MEASURE(S): Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients.
RESULT(S): Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas.
CONCLUSION(S): This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.
报告卡麦角林对与分泌促性腺激素的垂体腺瘤相关的卵巢过度刺激综合征的影响。
病例报告。
门诊实践。
两名月经不规律、卵巢增大、雌二醇（E₂）水平高且促性腺激素水平正常的女性。
卡麦角林治疗和经蝶窦手术。
雌二醇水平、经阴道超声检查和垂体磁共振成像。经蝶窦手术显示两名患者的垂体腺瘤均有促黄体生成素（LH）染色。
卡麦角林可有效降低E₂水平并减小卵巢大小，但对垂体腺瘤缩小无效。
这是首次描述卡麦角林作为分泌促性腺激素的垂体腺瘤患者自发性卵巢过度刺激综合征主要治疗方法的有效性。
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