Boll Daniel T, Hoffmann Martin H, Huber Nadine, Bossert Andrea S, Aschoff Andrik J, Fleiter Thorsten R
Department of Radiology, University Hospitals of Ulm, University of Ulm, Ulm, Germany.
J Comput Assist Tomogr. 2006 Sep-Oct;30(5):804-11. doi: 10.1097/01.rct.0000228162.70849.26.
To assess ex vivo specimens of atherosclerotic coronary arteries by dual energy (DE) multidetector computed tomography (MDCT) imaging, and to correlate depicted vessel lumen morphology and detected tissue characteristics with histopathologic analysis.
Coronary arteries were imaged on a 16-slice MDCT using a DE protocol consisting of a 90- and 140-kV scan. Coronary arteries were perfused with iodine- and gadolinium-based contrast agents. The DE K-edge subtractions were performed. Regions-of-interest were placed on histopathologically/radiographically-matched vascular lumen and wall, fibromuscular and calcified plaque, and fat tissues. Vascular/tissue contrast-to-noise ratios (CNR) were calculated, and their dependence on tissue type and contrast agent type was statistically evaluated.
Tissue CNR analysis confirmed that all tissue types were successfully distinguished. Vascular wall and fibromuscular plaque achieved a significant increase in CNR ratios when DE techniques were used compared with 140 kV protocols.
Spectral DE MDCT imaging of ex vivo atherosclerotic coronary arteries allows successful tissue characterization and enhances depiction of coronary lumen.
通过双能量（DE）多排螺旋计算机断层扫描（MDCT）成像评估动脉粥样硬化冠状动脉的离体标本，并将所描绘的血管腔形态和检测到的组织特征与组织病理学分析相关联。
使用由90 kV和140 kV扫描组成的DE方案在16层MDCT上对冠状动脉进行成像。用基于碘和钆的造影剂灌注冠状动脉。进行DE K边缘减法。在组织病理学/放射学匹配的血管腔和壁、纤维肌肉和钙化斑块以及脂肪组织上放置感兴趣区域。计算血管/组织对比噪声比（CNR），并对其对组织类型和造影剂类型的依赖性进行统计学评估。
组织CNR分析证实所有组织类型均成功区分。与140 kV方案相比，使用DE技术时血管壁和纤维肌肉斑块的CNR比值显著增加。
离体动脉粥样硬化冠状动脉的光谱DE MDCT成像可成功进行组织表征并增强冠状动脉腔的描绘。
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