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[短短芽孢杆菌变种G.——短芽孢杆菌P+变种与短杆菌肽S合成相关的放射生物学特性]

[The radiobiological characteristics of the P+ variant of Bacillus brevis var. G.--B. in relation to gramicidin S synthesis].

作者信息

Parkhomenko I M, Zarubina A P, Romanova N A, Kossova G V

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1990(3):48-55.

PMID:1695527
Abstract

The radiosensitivity of P(+) variant Bacillus brevis var. G.-B. cells cultured under condition of normal and inhibited gramicidin S synthesis, antibiotically high-active strain and high radioresistant cells has been studied. It has been shown that the radioresistance of bacterial cells correlates, in general, with their antibiotic activity: the antibiotic superproduced is more radioresistant than P(+) variant, the inhibition of antibiotic synthesis by beta-phenil-beta-alanin rises a little the sensitivity of P(+) variant cells. But the radioresistant fraction of P(+) variant contains the lower antibiotic amount than the whole population. It has been concluded that the radioprotective action of gramicidin S can not be the only reason of the above-mentioned differences in radiosensitivity.

摘要

对在正常条件和短杆菌肽S合成受抑制条件下培养的P(+)变异短芽孢杆菌G.-B.细胞、抗生素高活性菌株和高抗辐射细胞的辐射敏感性进行了研究。结果表明,细菌细胞的抗辐射性总体上与其抗生素活性相关:超量产生抗生素的细胞比P(+)变异细胞更具抗辐射性,β-苯基-β-丙氨酸对抗生素合成的抑制使P(+)变异细胞的敏感性略有提高。但P(+)变异细胞的抗辐射部分所含抗生素量低于整个群体。得出的结论是,短杆菌肽S的辐射防护作用不可能是上述辐射敏感性差异的唯一原因。

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