Siwela A H, Nyathi C B, Chetsanga C J, Hasler J A
Department of Biochemistry, University of Zimbabwe.
Biochem Pharmacol. 1990 Jul 15;40(2):379-82. doi: 10.1016/0006-2952(90)90703-n.
The covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate covalent binding of AAF to DNA. In addition, the extent of binding of AAF to liver macromolecules in vivo was generally less in infected than non-infected mice.
在感染曼氏血吸虫的小鼠和未感染的小鼠体内及体外，测定了[14C]乙酰氨基芴（AAF）与大分子的共价结合情况。感染小鼠的肝微粒体介导AAF与DNA共价结合的能力下降了42%。此外，在体内，AAF与感染小鼠肝脏大分子的结合程度通常低于未感染小鼠。
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