通过联合检测异型淋巴细胞和转氨酶诊断传染性单核细胞增多症。

Diagnosis of infectious mononucleosis by combined detection of atypical lymphocytes and transaminase.

作者信息

Hu Lihua, Yang Juhong, Cui Tianpen, Xing Hui, Cai Pengcheng

机构信息

Department of Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

出版信息

J Huazhong Univ Sci Technolog Med Sci. 2006;26(3):384-5. doi: 10.1007/BF02829584.

DOI:10.1007/BF02829584

PMID:16961302

Abstract

In order to explore the value of combined detection of atypical lymphocytes (ATL) and transaminase (alanine aminotransferase, ALT; asparate aminotransferase, AST) in the diagnosis of infectious mononucleosis (IM), The data of blood routine and liver function were collected from 54 IM patients, 34 acute hepatitis (AH) patients, 44 upper respiratory infection (URI) patients in Union Hospital during March 2002 to March 2005. Same data were also collected from 40 healthy children as normal control. These data were analyzed retrospectively. Both proportion of atypical lymphocytes and enzyme activity of transaminase were elevated simultaneously (ALT > 40 IU/L, AST > 45 IU/L) in 57.4% (31/54) IM patients. There was significant difference (P < 0.01) between IM group and the other groups. Combined detection of atypical lymphocytes and transaminase can be regarded as a diagnostic marker of infectious mononucleosis.

摘要

为探讨异型淋巴细胞（ATL）与转氨酶（谷丙转氨酶，ALT；谷草转氨酶，AST）联合检测在传染性单核细胞增多症（IM）诊断中的价值，收集了2002年3月至2005年3月间协和医院54例IM患者、34例急性肝炎（AH）患者、44例上呼吸道感染（URI）患者的血常规及肝功能数据。同时收集40例健康儿童的数据作为正常对照。对这些数据进行回顾性分析。57.4%（31/54）的IM患者异型淋巴细胞比例和转氨酶活性同时升高（ALT>40 IU/L，AST>45 IU/L）。IM组与其他组之间差异有统计学意义（P<0.01）。异型淋巴细胞与转氨酶联合检测可作为传染性单核细胞增多症的诊断标志物。