高效钯（0）介导的2-取代咪唑并[1,2-a]嘧啶的微波辅助芳基化反应

Efficient Pd(0)-mediated microwave-assisted arylation of 2-substituted imidazo[1,2-a]pyrimidines.

作者信息

Ermolat'ev D S, Giménez V N, Babaev E V, Van der Eycken E

机构信息

Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

出版信息

J Comb Chem. 2006 Sep-Oct;8(5):659-63. doi: 10.1021/cc060031b.

DOI:10.1021/cc060031b

PMID:16961403

Abstract

A short and practical synthesis of 2,3-substituted imidazo[1,2-a]pyrimidines, based on microwave-assisted Heck-type arylation of 2-substituted imidazo[1,2-a]pyrimidines, was developed. A 45-membered library of 2,3-substituted imidazo[1,2-a]pyrimidines was obtained with good yields and purities using this optimized protocol.

摘要

基于2-取代咪唑并[1,2-a]嘧啶的微波辅助Heck型芳基化反应，开发了一种简短且实用的2,3-取代咪唑并[1,2-a]嘧啶的合成方法。使用该优化方案，获得了一个包含45个成员的2,3-取代咪唑并[1,2-a]嘧啶文库，产率和纯度良好。