Müller Lutz A, Nowak Tobias E, Völk Michael, Pitto Rocco P, Pfander David, Forst Raimund, Schmidt Rainer, Eichinger Stephan
Orthopädische Klinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg am Waldkrankenhaus St. Marien, Rathsberger Str. 57, 91054 Erlangen, Deutschland.
Biomed Tech (Berl). 2006 Sep;51(3):139-44. doi: 10.1515/BMT.2006.023.
We prospectively analyzed the cancellous and cortical periprosthetic femoral bone reaction after implantation of a cementless total hip arthroplasty with computertomography assisted osteodensitometry after a mean of 1 and 6 years.
Twenty-one patients (Ø age at implantation: 52 years) with osteoarthrits of the hip joint received 21 cementless hip prostheses with a three-dimensionally tapered design. All patients were analyzed clinically, with CT-osteodensitometry and plain radiography after a mean of 10 days, at 1 and 6 years postoperatively. Cancellous and cortical bone density was evaluated automatically using a special software tool.
The proximal region of the stem showed progessive cortical (Ø -15% 1 year, -25% 6 years post-OP) and cancellous (Ø -26% 1 year, -49% 6 years post-OP) bone density loss. Cortical bone density loss was lower and non-progressive at the diaphysis (Ø -7% 1 year, -9% 6 years post-OP) and the distal region (Ø -6% 1 year, -4% 6 years post-OP) of the stem. All stems showed no signs of loosening on plain radiography and good clinical results according to the Harris hip score.
Computertomography assisted osteodensitometry is the only method which allows discrimination between periprosthetic cortical and cancellous bone density changes in vivo. The analyzed uncemented stem fixates at the diaphysis and distal region. Due to the changed biomechanical loading after stem implantation, progressive proximal cancellous bone density loss was measured for the first time in vivo. Its role in the pathogenesis of implant loosening is still unknown and needs to be further elucidated.
我们采用计算机断层扫描辅助骨密度测定法,对平均1年和6年后植入的非骨水泥型全髋关节置换术后股骨假体周围的松质骨和皮质骨反应进行了前瞻性分析。
21例髋关节骨关节炎患者(植入时平均年龄:52岁)接受了21个三维锥形设计的非骨水泥型髋关节假体。所有患者在术后平均10天、1年和6年时进行了临床分析、CT骨密度测定和X线平片检查。使用特殊软件工具自动评估松质骨和皮质骨密度。
假体柄近端区域的松质骨(术后1年平均降低26%,术后6年平均降低49%)和皮质骨(术后1年平均降低15%,术后6年平均降低25%)骨密度呈进行性降低。在假体柄的骨干(术后1年平均降低7%,术后6年平均降低9%)和远端区域(术后1年平均降低6%,术后6年平均降低4%),皮质骨密度降低幅度较小且无进行性变化。所有假体柄在X线平片上均无松动迹象,根据Harris髋关节评分临床效果良好。
计算机断层扫描辅助骨密度测定是唯一能够在体内区分假体周围皮质骨和松质骨密度变化的方法。所分析的非骨水泥型假体柄在骨干和远端区域固定良好。由于假体柄植入后生物力学负荷发生改变,首次在体内测量到近端松质骨骨密度呈进行性降低。其在植入物松动发病机制中的作用仍不清楚,需要进一步阐明。