骨髓纤维化白血病转化中的FLT3/D835突变及16号染色体倒位
FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis.
作者信息
Colovic Milica, Jurisic Vladimir, Pavlovic Sonja, Terzic Tatjana, Colovic Natasa
机构信息
Institute of Hematology, University Clinical Center, Belgrade, Serbia.
出版信息
Eur J Intern Med. 2006 Oct;17(6):434-5. doi: 10.1016/j.ejim.2006.02.028.
PMID:16962953
Abstract
We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course.
摘要
我们报告了一例非典型的骨髓纤维化发展为继发性白血病FAB亚型M4的病例，伴有16号染色体倒位、FLT3/D835点突变以及弥漫性溶骨性病变，并伴有肿瘤坏死因子-α升高。这些突变的同时出现反映了发展为继发性白血病的基因损伤与相对良性病程之间的渐进关联。
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