Nakai S
Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1990 Apr;64(4):229-39.
A strain of Japanese quail, SQOHM, is known as a model of idiopathic scoliosis in humans. It shows hereditary scoliotic deformities occurring in the cervical region. Histological, histochemical and serological studies were performed in 51 scoliotic and 109 non-scoliotic quail. Histological study revealed internal nuclei and tiny groups of small fibers in the neck muscles. The incidence of these, however, was only 19% in the scoliotic and 7% in the non-scoliotic quail. Histochemical observation with adenosine triphosphatase, phosphorylase and succinic dehydrogenase stains was made on the dorsal neck muscles. An increase in the number of beta-fibers, and a decrease in the number and hyperplasia of alpha-fibers were observed on the concave side of the scoliosis. The increase in number of beta-fibers on the concave side can play a role in promoting the deformity was suggested.
一种日本鹌鹑品系，即SQOHM，被认为是人类特发性脊柱侧凸的模型。它表现出颈部区域出现的遗传性脊柱侧凸畸形。对51只脊柱侧凸鹌鹑和109只非脊柱侧凸鹌鹑进行了组织学、组织化学和血清学研究。组织学研究显示颈部肌肉中有内部细胞核和小纤维小群。然而，这些在脊柱侧凸鹌鹑中的发生率仅为19%，在非脊柱侧凸鹌鹑中为7%。对颈背肌进行了三磷酸腺苷酶、磷酸化酶和琥珀酸脱氢酶染色的组织化学观察。在脊柱侧凸凹侧观察到β纤维数量增加，α纤维数量减少和增生。有人提出凹侧β纤维数量的增加可能在促进畸形方面起作用。
