解析化脓性链球菌中的调控网络：全局响应调节因子CovR直接抑制rivR。
Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly.
作者信息
Roberts Samantha A, Churchward Gordon G, Scott June R
机构信息
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
J Bacteriol. 2007 Feb;189(4):1459-63. doi: 10.1128/JB.01026-06. Epub 2006 Sep 8.
Abstract
The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.
摘要
应答调节因子CovR通过直接或间接抑制约15%的A组链球菌基因组转录，作为化脓性链球菌毒力的主要调节因子。我们证明，磷酸化的CovR通过与位于启动子下游的保守序列结合，直接抑制rivR的转录，从而阻止RNA聚合酶的前进。这在一个调节网络中建立了第一个联系，其中CovR直接与其他调节基因表达的蛋白质相互作用。
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