Pappas G, Panagopoulou P, Christou L, Akritidis N
Institute for Continuing Medical Education of Ioannina, Velissariou 15-19, 45221, Ioannina, Greece.
Cell Mol Life Sci. 2006 Oct;63(19-20):2229-36. doi: 10.1007/s00018-006-6311-4.
Brucella has traditionally been considered a biological weapon. It was the subject of extensive offensive research in the past, and still belongs to category B pathogens on most lists. Its propensity for airborne transmission and induction of chronic debilitating disease requiring combined antibiotic regimens for treatment, its abundance around the world and its vague clinical characteristics defying rapid clinical diagnosis are some of the characteristics that apply to the pathogen's weapons potential. Yet minimal mortality, availability of treatment options, protracted inoculation period and the emergence of new, more virulent potential weapons means that its inclusion among agents of bioterrorism is nowadays mainly of historical significance. Nevertheless, in the interest of literacy and of avoiding panic, physicians and the public both should be aware of the most common zoonosis worldwide.
布鲁氏菌传统上被视为一种生物武器。它在过去是广泛进攻性研究的对象,在大多数列表中仍属于B类病原体。它易于通过空气传播,能引发需要联合使用抗生素治疗的慢性衰弱性疾病,在世界各地分布广泛,且临床特征不明确,难以快速做出临床诊断,这些都是该病原体具备武器潜力的一些特征。然而,其死亡率低、有治疗选择、接种期长,以及新的、毒性更强的潜在武器的出现,意味着如今将其列入生物恐怖主义制剂主要只具有历史意义。尽管如此,为了知识普及和避免恐慌,医生和公众都应该了解这种全球最常见的人畜共患病。