Jiang Ning, Englehart Kevin B, Parker Philip A
Department of Electrical and Computer Engineering, Institute of Biomedical Engineering, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
J Electromyogr Kinesiol. 2007 Oct;17(5):527-34. doi: 10.1016/j.jelekin.2006.07.003. Epub 2006 Sep 14.
The firing sequences of motoneurons contain important information with regard to the underlying neural processes. Several methods have been proposed in the literature to simulate these sequences, however, one of the limitations is that they are not capable of simulating the complex neural dynamics of motor neurons, especially those of concurrently active ones, such as motor unit synchrony and motor unit common drive. In this paper, a novel model based on the Hodgkin-Huxley (HH) system is proposed, which has the ability to simulate the complex neurodynamics of the firing sequences of motor neurons. The model is presented at the cellular level and network level, and some simulation results from a simple 3-neuron network are presented to demonstrate its applications.
运动神经元的放电序列包含有关潜在神经过程的重要信息。文献中已经提出了几种方法来模拟这些序列,然而,其中一个局限性在于它们无法模拟运动神经元的复杂神经动力学,尤其是同时活跃的运动神经元的神经动力学,如运动单位同步性和运动单位共同驱动。在本文中,提出了一种基于霍奇金-赫胥黎(HH)系统的新型模型,该模型能够模拟运动神经元放电序列的复杂神经动力学。该模型在细胞水平和网络水平上进行了展示,并给出了一个简单三神经元网络的一些模拟结果以证明其应用。