用于生物传感的形状编码二氧化硅纳米管。

Shape-coded silica nanotubes for biosensing.

作者信息

He Bo, Son Sang Jun, Lee Sang Bok

机构信息

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.

出版信息

Langmuir. 2006 Sep 26;22(20):8263-5. doi: 10.1021/la060187t.

DOI:10.1021/la060187t

PMID:16981732

Abstract

Shape-coded silica nanotubes (SNTs) were fabricated on the basis of template synthesis as a new dispersible microarray system. The template synthesis of shape-coded SNTs begins with the fabrication of a porous alumina film that has well-defined cylindrical pores with two or more different diameter segments by multistep anodization of an aluminum substrate. Then, SNTs were fabricated with a surface sol-gel method that can control the wall thickness of SNTs on the single-nanometer level. Attractively, the difference in optical reflectance between the segmented parts of individual silica nanotube makes it very convenient to identify each nanotube and enables these shape-coded SNTs to work as coding materials for biosensing.

摘要

基于模板合成法制备了形状编码二氧化硅纳米管（SNTs），作为一种新型的可分散微阵列系统。形状编码SNTs的模板合成始于多孔氧化铝膜的制备，通过对铝基板进行多步阳极氧化，可得到具有两个或更多不同直径段的、孔径明确的圆柱形孔。然后，采用表面溶胶-凝胶法制备SNTs，该方法能够在单纳米水平上控制SNTs的壁厚。引人注目的是，单个二氧化硅纳米管各分段部分之间的光反射率差异使得识别每个纳米管非常方便，并使这些形状编码的SNTs能够用作生物传感的编码材料。