嗜热ATP合酶的γε亚复合体具有结合ATP的能力。
gammaepsilon Sub-complex of thermophilic ATP synthase has the ability to bind ATP.
作者信息
Iizuka Satoshi, Kato Shigeyuki, Yoshida Masasuke, Kato-Yamada Yasuyuki
机构信息
Department of Life Science, College of Science, Rikkyo University, 3-34-1, Nishi-Ikebukuro, Tokyo 171-8501, Japan.
出版信息
Biochem Biophys Res Commun. 2006 Nov 3;349(4):1368-71. doi: 10.1016/j.bbrc.2006.09.001. Epub 2006 Sep 11.
The isolated epsilon subunit of F(1)-ATPase from thermophilic Bacillus PS3 (TF(1)) binds ATP [Y. Kato-Yamada, M. Yoshida, J. Biol. Chem. 278 (2003) 36013]. The obvious question is whether the ATP binding concern with the regulation of ATP synthase activity or not. If so, the epsilon subunit even in the ATP synthase complex should have the ability to bind ATP. To check if the ATP binding to the epsilon subunit within the ATP synthase complex may occur, the gammaepsilon sub-complex of TF(1) was prepared and ATP binding was examined. The results clearly showed that the gammaepsilon sub-complex can bind ATP.
嗜热芽孢杆菌PS3的F(1)-ATP酶分离出的ε亚基（TF(1)）能结合ATP[加藤山田洋，吉田真人，《生物化学杂志》278 (2003) 36013]。一个显而易见的问题是，ATP结合是否与ATP合酶活性的调节有关。如果有关，那么即使在ATP合酶复合物中的ε亚基也应该具有结合ATP的能力。为了检验ATP合酶复合物中的ε亚基是否可能发生ATP结合，制备了TF(1)的γε亚复合物并检测了ATP结合情况。结果清楚地表明，γε亚复合物能够结合ATP。
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