Meyer Sascha, Löffler Günther, Polcher Thorsten, Gottschling Sven, Gortner Ludwig
Department of Neonatology and Paediatric Intensive Care, University Children's Hospital of Saarland, Homburg, Germany.
Acta Paediatr. 2006 Oct;95(10):1309-12. doi: 10.1080/08035250500538973.
To evaluate vasopressin as a rescue therapy in catecholamine-refractory septic and cardiogenic shock in very-low-birthweight (VLBW) infants.
Prospective assessment of vasopressin therapy in three VLBW infants with catecholamine-refractory septic shock (24 + 6 wk, 600 g) and cardiogenic shock (26 + 1 wk, 890 g; 26 + 1 wk, 880 g) at a university hospital.
Adequate systemic arterial blood pressure could only be restored after vasopressin administration as a continuous infusion over a 36-h period in the preterm suffering from septic shock; in the two neonates with cardiogenic shock, only a transient stabilization in mean arterial pressure was observed, which did not impact on the poor prognosis.
Although vasopressin appears to be a suitable rescue therapy in catecholamine-resistant septic shock in VLBW infants, further evaluation in controlled clinical trials is warranted.
评估血管加压素作为极低出生体重（VLBW）儿对儿茶酚胺难治性脓毒性休克和心源性休克的抢救治疗方法。
在一家大学医院对3例极低出生体重儿进行血管加压素治疗的前瞻性评估，其中2例为对儿茶酚胺难治性脓毒性休克（胎龄24 + 6周，体重600克），1例为心源性休克（胎龄26 + 1周，体重890克；胎龄26 + 1周，体重880克）。
在患有脓毒性休克的早产儿中，通过持续输注血管加压素36小时后才恢复了足够的体循环动脉血压；在2例心源性休克的新生儿中，仅观察到平均动脉压的短暂稳定，这对不良预后并无影响。
尽管血管加压素似乎是极低出生体重儿对儿茶酚胺抵抗性脓毒性休克的一种合适的抢救治疗方法，但仍需在对照临床试验中进行进一步评估。
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