Scofield R Hal, Bruner Gail R, Harley John B, Namjou Bahram
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Ann Rheum Dis. 2007 Mar;66(3):410-3. doi: 10.1136/ard.2006.055103. Epub 2006 Sep 19.
BACKGROUND: Autoimmune thyroid disease is common in systemic lupus erythematosus (SLE). About 20% of patients with SLE have secondary Sjögren's syndrome. METHODS: Families with more than one patient with SLE were identified. All patients met the revised classification criteria, although SLE-unaffected relatives were confirmed not to satisfy these criteria. Diagnosis of autoimmune thyroid disease and Sjögren's syndrome was made on the basis of a review of medical records, interview and questionnaire administered to patients with SLE, and by a questionnaire administered to SLE-unaffected subjects. RESULTS: Of a total of 1138 patients with SLE, 169 had a diagnosis of Sjögren's syndrome. Of these 50 (29.6%) patients also had autoimmune thyroid disease. Of the 939 patients with SLE with no diagnosis of Sjögren's syndrome, 119 (12.7%) had autoimmune thyroid disease (chi2 = 20.1, p = 0.000009). There was no association of a diagnosis of hypertension with secondary Sjögren's syndrome (42% vss 47%). Among 2291 SLE-unaffected relatives, 44 had diagnosed primary Sjögren's syndrome and 16 (36.3%) of these also had autoimmune thyroid disease. 265 of 2247 (11.8%) subjects had autoimmune thyroid disease but no Sjögren's syndrome (chi2 = 24.2, p<0.001). CONCLUSIONS: Autoimmune thyroid disease is found in excess among patients with SLE with a diagnosis of secondary Sjögren's syndrome, as well as among their SLE-unaffected relatives with a diagnosis of primary Sjögren's syndrome.
背景：自身免疫性甲状腺疾病在系统性红斑狼疮（SLE）中很常见。约20%的SLE患者患有继发性干燥综合征。 方法：确定有不止一名SLE患者的家庭。所有患者均符合修订后的分类标准，尽管已证实未受SLE影响的亲属不符合这些标准。自身免疫性甲状腺疾病和干燥综合征的诊断基于对SLE患者的病历审查、访谈和问卷调查，以及对未受SLE影响的受试者进行的问卷调查。 结果：在总共1138例SLE患者中，169例被诊断为干燥综合征。其中50例（29.6%）患者也患有自身免疫性甲状腺疾病。在939例未诊断为干燥综合征的SLE患者中，119例（12.7%）患有自身免疫性甲状腺疾病（χ2 = 20.1，p = 0.000009）。高血压诊断与继发性干燥综合征无关联（42%对47%）。在2291名未受SLE影响的亲属中，44例被诊断为原发性干燥综合征，其中16例（36.3%）也患有自身免疫性甲状腺疾病。2247名受试者中有265例（11.8%）患有自身免疫性甲状腺疾病但无干燥综合征（χ2 = 24.2，p<0.001）。 结论：在诊断为继发性干燥综合征的SLE患者中，以及在诊断为原发性干燥综合征的未受SLE影响的亲属中，自身免疫性甲状腺疾病的发生率过高。
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