Ding Ding, Wang Wenzhi, Wu Jianzhong, Ma Guangyu, Dai Xiuying, Yang Bin, Wang Taiping, Yuan Chenglin, Hong Zhen, de Boer Hanneke M, Prilipko Leonid, Sander Josemir W
Department of Biostatistics and Epidemiology, Institute of Neurology, Fudan University, WHO Collaborating Centre for Research and Training in Neurosciences, Shanghai, China.
Lancet Neurol. 2006 Oct;5(10):823-7. doi: 10.1016/S1474-4422(06)70528-2.
In China, few studies have described annual mortality associated with epilepsy in a general population and these have provided a range of 3.0-7.9 deaths per 100,000 people. We calculated the case fatality rate (CFR), proportional mortality rate (PMR), and standardised mortality ratio (SMR) to assess mortality in people with epilepsy in rural China.
The target population was people with epilepsy who participated in an assessment of epilepsy management at primary health level in rural China. Neurologists confirmed the diagnosis using strict criteria in all participants who were then treated with phenobarbital. Demographic data and putative cause of death were recorded for each person whose death was reported. PMRs for each cause of death and SMRs were estimated on the basis of the 2004 Chinese population.
Case fatality rate was 1.4% (35 deaths) among 2455 people with epilepsy. The age-adjusted PMRs for injury, stroke, neoplasm, myocardial infarction, and pneumonia were 30%, 30%, 15%, 6%, and 5%, respectively. The SMR was 3.9 (95% CI 3.8-3.9). Patients aged 15-29 years had higher mortality ratios than did those in other age-groups, with SMRs exceeding 23.
Risk for premature death is three to four times higher in people with epilepsy than in the general Chinese population. Furthermore, the risk in young people with epilepsy in China is much higher than previously reported. Injury, stroke, myocardial infarction, and pneumonia are among the leading putative causes of death in patients with epilepsy in rural China.
在中国，很少有研究描述普通人群中与癫痫相关的年死亡率，这些研究给出的范围是每10万人中有3.0 - 7.9人死亡。我们计算了病死率（CFR）、比例死亡率（PMR）和标准化死亡率（SMR），以评估中国农村癫痫患者的死亡率。
目标人群是参与中国农村基层癫痫管理评估的癫痫患者。神经科医生使用严格标准对所有参与者进行诊断，随后这些参与者接受苯巴比妥治疗。记录每例报告死亡者的人口统计学数据和推定死因。根据2004年中国人口数据估算每种死因的PMR和SMR。
2455例癫痫患者的病死率为1.4%（35例死亡）。损伤、中风、肿瘤、心肌梗死和肺炎的年龄调整后PMR分别为30%、30%、15%、6%和5%。SMR为3.9（95%CI 3.8 - 3.9）。15 - 29岁的患者死亡率高于其他年龄组，SMR超过23。
癫痫患者过早死亡的风险是中国普通人群的三到四倍。此外，中国年轻癫痫患者的风险比之前报道的要高得多。损伤、中风、心肌梗死和肺炎是中国农村癫痫患者主要的推定死因。
