Bechtold S, Dalla Pozza R, Schmidt H, Bonfig W, Schwarz H P
University Children's Hospital, Division of Pediatric Endocrinology, Munich, Germany.
J Pediatr Endocrinol Metab. 2006 Aug;19(8):987-93. doi: 10.1515/jpem.2006.19.8.987.
Short stature and ovarian failure are the main features in Ullrich-Turner syndrome (UTS). The aim of this retrospective analysis was to evaluate the influence of age at initiation of puberty on final height. Sixty-five girls were treated with growth hormone (GH) and had a final height of 150.6 +/- 5.7 cm; 12/65 entered puberty spontaneously. A non-GH treated group of 12 girls with UTS reached a final height of 147.3 +/- 6.6 cm. Subdividing the GH treated group (n = 53) based on the age at induction of puberty, before or after 13 years, there was no significant difference in final height. Final height was affected by the age at which GH treatment was initiated, height SDS at the beginning of puberty, and by the duration of GH therapy. Therefore, early treatment with GH for short stature in UTS should be attempted so that an age adequate initiation of puberty will be feasible.
身材矮小和卵巢功能衰竭是乌尔里希-特纳综合征（UTS）的主要特征。这项回顾性分析的目的是评估青春期开始年龄对最终身高的影响。65名女孩接受了生长激素（GH）治疗，最终身高为150.6±5.7厘米；65名中有12名自然进入青春期。一组未经GH治疗的12名UTS女孩最终身高为147.3±6.6厘米。根据青春期诱导年龄（13岁之前或之后）对接受GH治疗的组（n = 53）进行细分，最终身高没有显著差异。最终身高受开始GH治疗的年龄、青春期开始时的身高标准差分值以及GH治疗持续时间的影响。因此，对于UTS身材矮小应尝试早期使用GH治疗，以便能够在适当年龄开始青春期发育。
