自身免疫性炎性肌病（皮肌炎、多发性肌炎、包涵体肌炎）的治疗选择

Therapeutic options in autoimmune inflammatory myopathies (dermatomyositis, polymyositis, inclusion body myositis).

作者信息

Pongratz Dieter

机构信息

Friedrich-Baur-Institut, Medizinischen Fakultät, Neurologischen Klinik und Poliklinik, Ludwig Maximilians Universität München, Ziemssenstrasse 1, 80336, München, Germany.

出版信息

J Neurol. 2006 Sep;253 Suppl 5:V64-5. doi: 10.1007/s00415-006-5010-2.

DOI:10.1007/s00415-006-5010-2

PMID:16998756

Abstract

Polymyositis, dermatomyositis, and inclusion body myositis are idiopathic inflammatory myopathies of unknown etiology with autoimmune pathogenesis. For choosing an individual and efficient therapy, diagnostic assignment is an important factor. Therapeutic options in dermatomyositis and polymyositis include corticosteroids and immunosuppressives. Intravenous immunoglobulins are only needed in special cases. In inclusion body myositis, corticosteroids and immunosuppressives are not successful. At the moment intravenous immunoglobulins are the only therapeutic possibility.

摘要

多发性肌炎、皮肌炎和包涵体肌炎是病因不明、具有自身免疫发病机制的特发性炎性肌病。为选择个体化且有效的治疗方法，诊断分型是一个重要因素。皮肌炎和多发性肌炎的治疗选择包括皮质类固醇和免疫抑制剂。仅在特殊情况下需要静脉注射免疫球蛋白。在包涵体肌炎中，皮质类固醇和免疫抑制剂治疗无效。目前，静脉注射免疫球蛋白是唯一的治疗选择。