Ahmad Mufazzal, Shah Hemal, Pliakogiannis Theodori, Oreopoulos Dimitrios G
Department of Nephrology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto m5b2e8, Ontario, Canada.
Int Urol Nephrol. 2007;39(1):299-312. doi: 10.1007/s11255-006-9064-y. Epub 2006 Sep 27.
Peritoneal dialysis (PD) is now an established and successful alternative to hemodialysis. Multiple studies have confirmed its equivalent dialysis adequacy, mortality and fluid balance status, at least for the first 4-5 years. Peritoneal membrane failure is now one of the leading cause of technique failure. This review describes the role of glucose, glucose degradation product, pH, lactate, advanced glycosylation end product (AGE) in causing this membrane damage, and gives insight how the use of newer peritoneal dialysis fluids (PDFs) containing icodextrin, amino acids and bicarbonate buffer can prevent peritoneal membrane damage.
腹膜透析（PD）现已成为一种成熟且成功的血液透析替代方法。多项研究证实，至少在最初4至5年，其透析充分性、死亡率及液体平衡状况相当。腹膜衰竭如今是技术失败的主要原因之一。本综述描述了葡萄糖、葡萄糖降解产物、pH值、乳酸、晚期糖基化终产物（AGE）在导致这种膜损伤中的作用，并深入探讨了使用含艾考糊精、氨基酸和碳酸氢盐缓冲液的新型腹膜透析液（PDFs）如何预防腹膜损伤。
