Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis.
作者信息
Komizu Yuji, Matsumoto Yoko, Ueoka Ryuichi
机构信息
Graduate Course of Applied Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
出版信息
Bioorg Med Chem Lett. 2006 Dec 1;16(23):6131-4. doi: 10.1016/j.bmcl.2006.08.099. Epub 2006 Sep 26.
PMID:17005395
Abstract
A good correlation between 50% inhibitory concentration of hybrid liposomes (HL) composed of 90 mol% dimyristoylphosphatidylcholine and 10 mol% polyoxyethylene(n)dodecyl ether on the growth of human colon tumor (WiDr) cells, and membrane fluidity of HL was obtained. HL distinguished between WiDr and normal colon cells and then fused and accumulated into the membranes of WiDr cells leading to apoptosis.
摘要
Zotero 插件