CHEK2*1100delC种系突变与雌激素受体状态之间的关联。
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status.
作者信息
de Bock G H, Mourits M J E, Schutte M, Krol-Warmerdam E M M, Seynaeve C, Blom J, Brekelmans C T M, Meijers-Heijboer H, van Asperen C J, Cornelisse C J, Devilee P, Tollenaar R A E M, Klijn J G M
机构信息
Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
出版信息
Int J Gynecol Cancer. 2006;16 Suppl 2:552-5. doi: 10.1111/j.1525-1438.2006.00694.x.
Already published data were further analyzed regarding the association between the CHEK21100delC germ line mutation and estrogen receptor (ER) status in patients with breast cancer. The CHEK21100delC mutation was more prevalent among the patients with a positive ER status (4.2% versus 1.0%). An ER-negative status was beside CHEK21100delC mutation and independently associated with an earlier of age onset of breast cancer. There was a trend that an ER-negative status, beside the presence of a CHEK21100delC mutation, was associated with a worse disease-free survival. There might be an association between ER status and a CHEK21100delC mutation. More studies with larger number of patients are needed to further investigate the relation between CHEK21100delC and ER status.
我们进一步分析了已发表的数据，以研究乳腺癌患者中CHEK21100delC种系突变与雌激素受体（ER）状态之间的关联。CHEK21100delC突变在ER阳性状态的患者中更为普遍（4.2%对1.0%）。除CHEK21100delC突变外，ER阴性状态与乳腺癌发病年龄较早独立相关。有一种趋势是，除存在CHEK21100delC突变外，ER阴性状态与无病生存期较差相关。ER状态与CHEK21100delC突变之间可能存在关联。需要更多对大量患者的研究来进一步探究CHEK21100delC与ER状态之间的关系。
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