小儿原发性膈肌肿瘤的诊断与治疗方法
Approach to diagnosis and treatment of pediatric primary tumors of the diaphragm.
作者信息
Cada Michaela, Gerstle J Ted, Traubici Jeffrey, Ngan Bo-Yee, Capra Michael L
机构信息
Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
出版信息
J Pediatr Surg. 2006 Oct;41(10):1722-6. doi: 10.1016/j.jpedsurg.2006.05.073.
BACKGROUND/PURPOSE: Tumors of the diaphragm in the pediatric population are extremely rare. We present 5 cases diagnosed at the Hospital for Sick Children, Toronto, and together with a review of the world literature, provide an approach to the diagnosis and management of these tumors.
METHODS
A clinical retrospective review of patients diagnosed as having primary diaphragmatic tumor (PDT) at the Hospital for Sick Children as well as a review of the world literature.
RESULTS
Forty-one cases of PDT in the pediatric population have been described from 1868 to 2005 inclusive. There is an equal incidence in boys and girls, they are found with the same frequency on the left as on the right, and 78% are malignant. Rhabdomyosarcoma is the most commonly occurring malignant tumor. The mean age at diagnosis is 10 years. "Chest-associated" symptoms are more common than "abdomen-associated" symptoms. Imaging often fails to identify the site of origin as the diaphragm. Surgery is the cornerstone of therapy for PDT.
CONCLUSION
A multidisciplinary team approach is needed for successful treatment and management of PDT.
背景/目的：小儿膈肿瘤极为罕见。我们报告了在多伦多病童医院诊断出的5例病例，并结合对世界文献的回顾，提供了这些肿瘤的诊断和管理方法。
方法
对在病童医院被诊断为原发性膈肿瘤（PDT）的患者进行临床回顾性研究，并对世界文献进行回顾。
结果
从1868年至2005年（含），共描述了41例小儿PDT病例。男女发病率相等，左右侧发现频率相同，78%为恶性。横纹肌肉瘤是最常见的恶性肿瘤。诊断时的平均年龄为10岁。“胸部相关”症状比“腹部相关”症状更常见。影像学检查常常无法确定肿瘤起源于膈肌。手术是PDT治疗的基石。
结论
成功治疗和管理PDT需要多学科团队协作。
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