使用生物分配胶束色谱法的心血管系统药物的QRAR模型
QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography.
作者信息
Wang Sumin, Yang Gengliang, Zhang Hua, Liu Haiyan, Li Zhiwei
机构信息
College of Pharmacy, Hebei University, Baoding 071002, China; Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China.
出版信息
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):329-33. doi: 10.1016/j.jchromb.2006.08.027. Epub 2006 Sep 29.
The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C(18) stationary phase. Quantitative retention-activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD(50)) of cardiovascular system drugs was obtained.
生物分配胶束色谱法（BMC）描述和估算心血管系统药物药理学参数的能力已得到研究。在改性C(18)固定相中，使用不同pH值的Brij-35作为胶束流动相，研究了心血管系统药物的保留情况。对这些化合物研究了生物分配胶束色谱法中的定量保留-活性关系（QRAR）。得到了心血管系统药物的保留因子（log k）与毒性（LD(50)）之间的适当相关性。
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