在神经病变和非恶性IgM单克隆丙种球蛋白病中表达抗MAG抗体的B细胞属于CD5亚群。

The B-cells that express anti-MAG antibodies in neuropathy and non-malignant IgM monoclonal gammopathy belong to the CD5 subpopulation.

作者信息

Lee K W, Inghirami G, Spatz L, Knowles D M, Latov N

机构信息

Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.

出版信息

J Neuroimmunol. 1991 Jan;31(1):83-8. doi: 10.1016/0165-5728(91)90090-t.

DOI:10.1016/0165-5728(91)90090-t

PMID:1701449

Abstract

B-cells that express monoclonal IgM anti-MAG antibodies (M-protein) in a patient with neuropathy and non-malignant IgM monoclonal gammopathy were studied by flow cytometry to determine if they bear the CD5 cell surface antigen. The CD5+ antigen is expressed on a subpopulation of B-cells which has been implicated in the secretion of autoantibodies and development of B-cell chronic lymphocytic leukemia (B-CLL). The monoclonal anti-MAG antibodies secreting B-cells were identified by a mouse monoclonal antibody to M-protein idiotype. Cytofluorometric analysis revealed that approximately 62% of the idiotype-positive B-lymphocytes expressed the CD5 antigen. The result of this study indicate that monoclonal anti-MAG antibodies may be secreted by CD5+ B-cells, and that B-cells in some cases of non-malignant IgM monoclonal gammopathy may be phenotypically similar to B-CLL cells.

摘要

通过流式细胞术研究了一名患有神经病变和非恶性IgM单克隆丙种球蛋白病的患者中表达单克隆IgM抗MAG抗体（M蛋白）的B细胞，以确定它们是否携带CD5细胞表面抗原。CD5 +抗原在一部分B细胞上表达，这部分B细胞与自身抗体的分泌和B细胞慢性淋巴细胞白血病（B - CLL）的发生有关。分泌单克隆抗MAG抗体的B细胞通过针对M蛋白独特型的小鼠单克隆抗体进行鉴定。细胞荧光分析显示，约62%的独特型阳性B淋巴细胞表达CD5抗原。这项研究的结果表明，单克隆抗MAG抗体可能由CD5 + B细胞分泌，并且在某些非恶性IgM单克隆丙种球蛋白病病例中，B细胞在表型上可能与B - CLL细胞相似。