蛋白质tau富含脯氨酸的结构域和微管结合结构域可作为RNA结合结构域。

The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.

作者信息

Wang XingSheng, Wang DongLiang, Zhao Jing, Qu MeiHua, Zhou XiaoHong, He HaiJin, He RongQiao

机构信息

State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China.

出版信息

Protein Pept Lett. 2006;13(7):679-85. doi: 10.2174/092986606777790566.

DOI:10.2174/092986606777790566

PMID:17018010

Abstract

Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

摘要

神经元tau蛋白通过其富含脯氨酸的结构域和微管结合结构域，通过静电相互作用与RNA进行非序列特异性结合。这种结合会抑制tau蛋白的活性。在SH-SY5Y细胞中还发现tau蛋白与RNA共定位，这表明RNA在细胞中有机会与tau蛋白相互作用。