Albazaz R, Da Costa P E, Verbeke C S
Department of Histopathology, St James's University Hospital Leeds, Leeds, UK.
J Clin Pathol. 2006 Oct;59(10):1087-90. doi: 10.1136/jcp.2005.030478.
A case of pancreatic polypeptide cell hyperplasia in a 76-year-old man who presented with subacute bowel pseudo-obstruction is reported. A computed tomography scan incidentally showed a pancreatic head lesion that was resected by pancreaticoduodenectomy. Histological examination showed expansion of the endocrine pancreas with increased numbers of pancreatic polypeptide cells in irregularly enlarged islets, ragged endocrine cell clusters, ductulo-insular complexes and microadenomas. The clinicopathological features of this rare and poorly understood condition are discussed.
报告了一例76岁男性胰腺多肽细胞增生症,该患者表现为亚急性假性肠梗阻。计算机断层扫描偶然发现胰头部病变,遂行胰十二指肠切除术将其切除。组织学检查显示内分泌胰腺扩张,不规则增大的胰岛、参差不齐的内分泌细胞簇、导管胰岛复合体和微腺瘤中胰腺多肽细胞数量增加。本文讨论了这种罕见且了解甚少的疾病的临床病理特征。