Banks William A
GRECC, Veterans Affairs Medical Center-St. Louis, Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N. Grand Boulevard, St. Louis, MO, USA.
Obesity (Silver Spring). 2006 Aug;14 Suppl 5:234S-237S. doi: 10.1038/oby.2006.315.
The blood-brain barrier (BBB) plays a critical role in the transduction of signals between the central nervous system and peripheral tissues. It does so through several mechanisms, including the direct transport of peptides and regulatory proteins such as insulin and leptin. Another mechanism that may be important is the secretion by brain endothelial cells of substances that affect feeding, such as proinflammatory cytokines and NO. We have recently shown that the BBB is capable of receiving an input from one side and secreting a substance into the other. Additionally, BBB secretions can be modulated by substances that affect feeding, such as adiponectin and lipopolysaccharide.
血脑屏障（BBB）在中枢神经系统与外周组织之间的信号转导中起着关键作用。它通过多种机制来实现这一点，包括肽和调节蛋白如胰岛素和瘦素的直接转运。另一个可能重要的机制是脑内皮细胞分泌影响进食的物质，如促炎细胞因子和一氧化氮。我们最近发现，血脑屏障能够从一侧接收输入并向另一侧分泌物质。此外，血脑屏障的分泌可受到影响进食的物质如脂联素和脂多糖的调节。
