甘丙肽刺激体外灌流的大鼠下丘脑切片中免疫反应性生长激素释放因子的分泌。
Galanin stimulates immunoreactive growth hormone-releasing factor secretion from rat hypothalamic slices perifused in vitro.
作者信息
Kitajima N, Chihara K, Abe H, Okimura Y, Shakutsui S
机构信息
Department of Medicine, Kobe University School of Medicine, Japan.
出版信息
Life Sci. 1990;47(25):2371-6. doi: 10.1016/0024-3205(90)90277-x.
PMID:1702174
Abstract
The effect of galanin (GAL) on the release of GH-releasing factor (GRF) and somatostatin (SRIF) was examined in an in vitro perifusion system of rat hypothalamic slices. GAL at doses of 10(-7) and 10(-6)M stimulated the release of immunoreactive GRF while it failed to affect SRIF release. Therefore, in vivo stimulation of GH release by GAL may be explained in part by the GRF-releasing effect of this peptide.
摘要
在大鼠下丘脑切片的体外灌流系统中，研究了甘丙肽（GAL）对生长激素释放因子（GRF）和生长抑素（SRIF）释放的影响。10^(-7)和10^(-6)M剂量的GAL刺激了免疫反应性GRF的释放，而对SRIF的释放没有影响。因此，GAL在体内对生长激素释放的刺激作用可能部分归因于该肽的GRF释放效应。
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