苯丙胺引起的食欲致敏不会降低其产生对糖精的条件性味觉厌恶的能力。
Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin.
作者信息
Scott-Railton John, Arnold Gretchen, Vezina Paul
机构信息
Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, MC 3077, Chicago, IL 60637, USA.
出版信息
Behav Brain Res. 2006 Dec 15;175(2):305-14. doi: 10.1016/j.bbr.2006.08.036. Epub 2006 Oct 4.
Abstract
Previous exposure to amphetamine attenuates its ability to induce conditioned taste aversion (CTA). Because amphetamine, unlike emetic agents like LiCl, possesses appetitive properties that sensitize when it is administered repeatedly, the present study assessed the contribution of sensitization to this US-pre-exposure effect (US-PEE). It was found that not all sensitizing regimens of systemic amphetamine injections produce a US-PEE. In addition, previous exposure to amphetamine in the VTA, where it acts to induce sensitization but not CTA, did not produce a US-PEE. It is concluded that amphetamine sensitization alone does not modulate this drug's ability to produce CTA. Implications of these findings for anatomically based associative and non-associative models of CTA and the US-PEE are discussed.
摘要
先前接触苯丙胺会减弱其诱导条件性味觉厌恶（CTA）的能力。由于苯丙胺与氯化锂等催吐剂不同，具有反复给药时会敏感化的食欲增强特性，因此本研究评估了敏感化对这种非条件刺激预暴露效应（US-PEE）的作用。研究发现，并非所有全身性苯丙胺注射的敏感化方案都会产生US-PEE。此外，先前在腹侧被盖区接触苯丙胺，苯丙胺在该区域起到诱导敏感化而非CTA的作用，并未产生US-PEE。研究得出结论，仅苯丙胺敏感化并不能调节该药物产生CTA的能力。讨论了这些发现对基于解剖学的CTA和US-PEE关联及非关联模型的意义。
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