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经鼻后神经切除术治疗特发性味觉性鼻溢

Treatment of idiopathic gustatory rhinorrhea by resection of the posterior nasal nerve.

作者信息

Ang Yah Yee, Kawano Kenji, Saito Tatsuya, Kasai Misato, Ikeda Katsuhisa

机构信息

Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Tohoku J Exp Med. 2006 Oct;210(2):165-8. doi: 10.1620/tjem.210.165.

Abstract

We herein describe a case of 44-year old female who presented with a chief complaint of gustatory rhinorrhea from childhood, in which gustatory stimuli caused bilateral excessive, watery nasal secretion. No abnormality of taste acuity was observed. This disorder was presumably caused by faulty regenerated parasympathetic nerve fibers reaching the nasal mucosa or possibly, by a congenital condition. Nasal pretreatment with an anti-cholinergic drug clinically blocked the positive sugar-induced rhinorrhea, thus indicating that the gustatory rhinitis in this case was produced by foods that stimulate muscarinic receptors sensitive to atropine (probably on submucosal nasal glands). Although this syndrome can be treated prophylactically by the use of topical atropine, the patient preferred to undergo radical therapy and a resection of the posterior nasal nerve was performed through the middle meatus under endoscopic control. The resection of the nerve on both sides resulted in an almost complete inhibition of the sugar-induced rhinorrhea without serious complications. Although this disease is not life-threatening, it is socially embarrassing and troublesome to patients and surgical therapy is one of the accepted modalities.

摘要

我们在此描述一例44岁女性病例,该患者自童年起就以味觉性鼻溢液为主诉,即味觉刺激可导致双侧鼻腔分泌过多水样分泌物。未观察到味觉敏锐度异常。这种疾病推测是由于再生的副交感神经纤维到达鼻黏膜出现故障,或者可能是先天性疾病所致。临床上用抗胆碱能药物进行鼻腔预处理可阻断阳性糖诱导的鼻溢液,这表明该病例中的味觉性鼻炎是由刺激对阿托品敏感的毒蕈碱受体的食物(可能位于鼻黏膜下腺体)引起的。尽管该综合征可通过局部使用阿托品进行预防性治疗,但患者更倾向于接受根治性治疗,于是在内镜控制下经中鼻道对后鼻神经进行了切除。双侧神经切除几乎完全抑制了糖诱导的鼻溢液,且无严重并发症。虽然这种疾病不会危及生命,但会给患者带来社交尴尬和困扰,手术治疗是公认的治疗方式之一。

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