结合疫苗接种前澳大利亚中部侵袭性肺炎球菌疾病的流行病学变化：一项为期16年的研究。
Changing epidemiology of invasive pneumococcal disease in central Australia prior to conjugate vaccine: a 16-year study.
作者信息
Torzillo Paul J, Morey Frances, Gratten Mike, Murphy Denise, Matters Rex, Dixon Jeannette
机构信息
Department of Medicine, University of Sydney, Suite 420 RPAH Medical Centre, 100 Carillon Avenue, Newtown, Sydney, NSW 2042, Australia.
出版信息
Vaccine. 2007 Mar 22;25(13):2375-8. doi: 10.1016/j.vaccine.2006.09.003. Epub 2006 Sep 20.
This study reports a 16-year prospective surveillance of invasive disease isolates in central Australian Aborigines. There were 621 (89.6% of total) isolates recovered from Aborigines. The mortality in children less than 5 years of age was 4% but rose to 34.5% in those over 49 years of age. The study documented continuing high rates of disease overall, but with significant reductions in incidence rates for children. In children under 2 years of age, the incidence fell by 32% from 2053 per 100,000 in the period 1985-1990 to 1184 per 100,000 in the period 1996-2000. Rates of disease in adults showed no reduction despite an adult immunisation programme with 23 valent vaccine which occurred in the 1990s. Epidemics of serotypes 1, 5 and 12F were documented during the study period.
本研究报告了对澳大利亚中部原住民侵袭性疾病分离株进行的为期16年的前瞻性监测。从原住民中分离出621株（占总数的89.6%）。5岁以下儿童的死亡率为4%，但49岁以上人群的死亡率升至34.5%。该研究记录了总体疾病发病率持续居高不下的情况，但儿童发病率显著下降。在2岁以下儿童中，发病率从1985 - 1990年期间的每10万人2053例下降了32%，至1996 - 2000年期间的每10万人1184例。尽管在20世纪90年代开展了成人23价疫苗免疫计划，但成人疾病发病率并未降低。在研究期间记录到了1、5和12F血清型的流行情况。
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