Boss Andreas, Martirosian Petros, Küper Klaus, Fierlbeck Gerhard, Claussen Claus D, Schick Fritz
Section of Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University, Tübingen, Germany.
J Magn Reson Imaging. 2006 Nov;24(5):1183-7. doi: 10.1002/jmri.20754.
To demonstrate the feasibility of whole-body magnetization transfer (MT) contrast imaging.
Whole-body MT imaging was performed on eight healthy volunteers and five patients (mean age=40.5+/-17.8 years) with diagnoses of dermatomyositis (N=1), B-symptoms with suspicion of paraneoplastic disease (N=1), metastatic malignant melanoma (N=1), and multiple sclerosis (MS) (N=2). Measurements were carried out on a 1.5-Tesla whole-body MR scanner capable of parallel signal reception. A three-dimensional (3D) gradient-echo sequence (TR=17 msec, TE=4.8 msec, flip angle=10 degrees) was applied in combination with a Gaussian off-resonance MT preparation pulse acting at an off-resonance of 1.500 Hz with a 500 degrees effective flip angle. Whole-body images were constructed from five different body regions.
In all subjects, whole-body MT contrast images were obtained within less than 20 minutes of measuring time. The images showed sufficient diagnostic image quality to assess the patients' pathologies. The MT ratios (MTRs, in percent units) for the volunteers were as follows: white matter (WM) 51.1+/-1.0, gray matter (GM) 42.2+/-1.3, skeletal muscle (mean value of four muscle groups) 50.3+/-2.1, liver 39.4+/-3.2, spleen 31.8+/-2.6, renal cortex 30.4+/-1.9, and renal medulla 25.6+/-1.3. The MTRs for the pathologies were as follows: skeletal muscle in dermatomyositis approximately 30, metastases in malignant melanoma 30.7-36.0, uterus myoma 49.3, and MS lesions 30-40.
Our preliminary data indicate that MT contrast in whole-body MRI is feasible, and may be useful for rapid whole-body assessment of diseases that exhibit high contrast in MT imaging, such as MS and muscular disorders.
证明全身磁化传递（MT）对比成像的可行性。
对8名健康志愿者和5名患者（平均年龄 = 40.5±17.8岁）进行全身MT成像，这些患者的诊断分别为皮肌炎（n = 1）、怀疑副肿瘤性疾病的B症状（n = 1）、转移性恶性黑色素瘤（n = 1）和多发性硬化症（MS）（n = 2）。测量在一台能够进行并行信号接收的1.5特斯拉全身MR扫描仪上进行。应用三维（3D）梯度回波序列（TR = 17毫秒，TE = 4.8毫秒，翻转角 = 10度），并结合一个高斯失谐MT准备脉冲，该脉冲在1500赫兹的失谐频率下作用，有效翻转角为500度。从五个不同的身体区域构建全身图像。
在所有受试者中，测量时间不到20分钟就获得了全身MT对比图像。这些图像显示出足够的诊断图像质量来评估患者的病情。志愿者的MT比率（MTR，以百分比为单位）如下：白质（WM）51.1±1.0，灰质（GM）42.2±1.3，骨骼肌（四个肌肉组的平均值）50.3±2.1，肝脏39.4±3.2，脾脏31.8±2.6，肾皮质30.4±1.9，肾髓质25.6±1.3。病变的MTR如下：皮肌炎中的骨骼肌约为30，恶性黑色素瘤转移灶为30.7 - 36.0，子宫肌瘤为49.3，MS病变为30 - 40。
我们的初步数据表明，全身MRI中的MT对比是可行的，并且可能有助于对MT成像中具有高对比度的疾病进行快速全身评估，如MS和肌肉疾病。
