Purvis D J, Harper J I, Hartley B E, Sebire N J
Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.
Br J Dermatol. 2006 Nov;155(5):1041-4. doi: 10.1111/j.1365-2133.2006.07468.x.
Positive immunohistochemical staining for glucose transporter-1 protein (GLUT1) is a characteristic of cutaneous infantile haemangiomas.
To examine GLUT1 expression in subglottic haemangiomas.
Review of clinical notes and biopsy tissue with immunostaining for GLUT1 in 14 patients with subglottic haemangiomas.
GLUT1 immunostaining was negative in 11 cases, and focally positive in three. No subglottic haemangiomas demonstrated the intense diffuse positive GLUT1 staining seen in cutaneous infantile haemangiomas. Five patients had cutaneous as well as subglottic haemangiomas, one of whom had a GLUT1-negative subglottic haemangioma and a GLUT1-positive cutaneous haemangioma of the lip.
Subglottic haemangiomas appear immunohistochemically different from cutaneous infantile haemangiomas, which may reflect differences in endothelial cell differentiation or underlying aetiology.
葡萄糖转运蛋白-1（GLUT1）蛋白的免疫组化染色阳性是皮肤婴幼儿血管瘤的一个特征。
检测声门下血管瘤中GLUT1的表达情况。
回顾14例声门下血管瘤患者的临床记录及活检组织，并对其进行GLUT1免疫染色。
11例GLUT1免疫染色为阴性，3例为局灶性阳性。没有声门下血管瘤表现出皮肤婴幼儿血管瘤中所见的强烈弥漫性GLUT1阳性染色。5例患者同时患有皮肤和声门下血管瘤，其中1例患者的声门下血管瘤为GLUT1阴性，唇部皮肤血管瘤为GLUT1阳性。
声门下血管瘤在免疫组化上似乎与皮肤婴幼儿血管瘤不同，这可能反映了内皮细胞分化或潜在病因的差异。
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