精神分裂症患者接受抗精神病药物治疗后临床与生化变化之间的关系。

The relationship between clinical and biochemical changes following neuroleptic treatment in schizophrenia.

作者信息

Cooper S J, Leahey W, Liddle J, King D J

机构信息

Department of Mental Health, Queen's University of Belfast, Northern Ireland, U.K.

出版信息

Schizophr Res. 1990 Jul-Aug;3(4):261-7. doi: 10.1016/0920-9964(90)90007-t.

DOI:10.1016/0920-9964(90)90007-t

PMID:1703780

Abstract

Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical changes occurring in the patients. The results can be explained in terms of dopamine receptor changes in a way that is compatible with the Dopamine Hypothesis for schizophrenia.

摘要

开始使用抗精神病药物治疗时，精神病症状的临床改善并非立竿见影。先前的研究已证明，机体对抗精神病药物作用于多巴胺系统会产生生化耐受性。本研究表明了这种生化变化与患者临床变化之间的关系。这些结果可以用与精神分裂症多巴胺假说相符的方式，从多巴胺受体变化的角度来解释。