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[性别特异性抗高血压药物治疗]

[Sex-specific antihypertensive drug therapy].

作者信息

Pühringer Petra, Gouya Ghazaleh, Reichardt Berthold, Wolzt Michael

机构信息

Universitätsklinik für Klinische Pharmakologie, Medizinische Universität Wien, Wien, Austria.

出版信息

Wien Med Wochenschr. 2006 Sep;156(17-18):498-500. doi: 10.1007/s10354-006-0334-1.

Abstract

BACKGROUND

Hypertension is a leading cause of cardiovascular diseases. To evaluate sex-specific differences in the prescription pattern of antihypertensive therapy, registry data from the regional health insurance fund "Burgenländische Gebietskrankenkasse" (BGKK) were analyzed.

MATERIAL AND METHODS

In a retrospective cross sectional cohort study data from 41499 individuals covered by the BGKK in 2003, and who had been treated with cardiovascular drugs were analyzed. Data were evaluated according to drug classifications.

RESULTS

Among subjects treated with cardiovascular medication 38.3 % were males and 61.7 % females. The drug classes acting on the renin-angiotensin-system were prescribed more frequently than beta-blockers, calcium channel blockers, diuretics and antihypertensives. Women were treated more often with diuretics and beta-blockers, whereas men received more antihypertensives and drugs acting on the renin angiotensin system (p < 0.01 between groups of sexes).

CONCLUSION

Sex-specific differences exist regarding the prevalence of antihypertensive drug prescriptions between men and women. Further, the prescription pattern of equivalently effective medications differs between sexes.

摘要

背景

高血压是心血管疾病的主要病因。为评估抗高血压治疗处方模式中的性别差异,对地区健康保险基金“布尔根兰州地区医疗保险公司”(BGKK)的登记数据进行了分析。

材料与方法

在一项回顾性横断面队列研究中,分析了2003年BGKK所涵盖的41499名接受心血管药物治疗的个体的数据。根据药物分类对数据进行评估。

结果

在接受心血管药物治疗的受试者中,男性占38.3%,女性占61.7%。作用于肾素-血管紧张素系统的药物类别比β受体阻滞剂、钙通道阻滞剂、利尿剂和抗高血压药物的处方频率更高。女性使用利尿剂和β受体阻滞剂治疗的频率更高,而男性接受更多的抗高血压药物和作用于肾素-血管紧张素系统的药物(两性之间p<0.01)。

结论

男性和女性在抗高血压药物处方的患病率方面存在性别差异。此外,等效有效药物的处方模式在性别之间也有所不同。

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