Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?
作者信息
Ferretti G, Alimonti A, Cognetti F
出版信息
Br J Cancer. 2006 Nov 6;95(9):1304-5; author reply 1306-7. doi: 10.1038/sj.bjc.6603424. Epub 2006 Oct 17.
Abstract
摘要
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Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?
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本文引用的文献
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Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481).
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Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients.
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Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy.
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Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.
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Can colorectal cancer patients with thymidylate synthase-overexpressing liver metastases have an overall survival advantage with hepatic arterial infusion alone?
J Clin Oncol. 2003 Sep 15;21(18):3543-4; author reply 3544-5. doi: 10.1200/JCO.2003.99.075.
7
Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer.
J Clin Oncol. 2003 Feb 1;21(3):406-12. doi: 10.1200/JCO.2003.06.060.
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Detection of thymidylate synthase modulators by a novel screening assay.
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A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil.
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