Seldin Michael F, Shigeta Russell, Villoslada Pablo, Selmi Carlo, Tuomilehto Jaakko, Silva Gabriel, Belmont John W, Klareskog Lars, Gregersen Peter K
Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America.
PLoS Genet. 2006 Sep 15;2(9):e143. doi: 10.1371/journal.pgen.0020143. Epub 2006 Jul 25.
Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between "northern" and "southern" European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the "southern" population; and most northern, western, eastern, and central Europeans have >90% in the "northern" population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the "southern" population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.
通过全基因组单核苷酸多态性（SNP）分析，我们在一群多样化的欧洲人和欧裔美国人中观察到了群体结构。在各种条件和测试下，“北欧”和“南欧”人群组之间存在一致且可重复的区别：大多数有南欧血统（意大利、西班牙、葡萄牙和希腊）的个体参与者在“南欧”群体中的成员比例>85%；而大多数北欧、西欧、东欧和中欧人在“北欧”群体中的比例>90%。阿什肯纳兹犹太人和西班牙系犹太人的起源在“南欧”群体中的成员比例也>85%，这与这些族群后来来自地中海地区的起源一致。基于这项工作，我们开发了一组核心的信息丰富的SNP标记，可在各种临床和遗传研究中控制欧洲人群结构中的这种划分。
