苯丙氨酸对雏鸡（家鸡）胰腺淀粉酶分泌的影响。

Effect of phenylalanine on pancreatic amylase secretion in chicks (Gallus domesticus).

Yang S I, Furuse M, Sugishita N, Okumura J

Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.

Comp Biochem Physiol A Comp Physiol. 1990;97(4):531-3. doi: 10.1016/0300-9629(90)90122-9.

Abstract

Effect of phenylalanine (Phe) on pancreatic amylase secretion in growing chicks was investigated in four experiments. 2. In Experiment 1, birds were injected through a wing vein with 0.25 ml Phe at 0, 0.1, 0.5, 2.5 and 12.5 mM in physiological saline. No significant difference was observed in amylase secretion among treatments. 3. Effect of various concentrations of Phe with cholecystokinin (CCK, 0.31 Crick unit) on amylase secretion was investigated in Experiment 2. Amylase secretion increased with time, although no significant effect was detected in Phe treatment. 4. Efficacy of Phe and tyrosine (Tyr) injection with CCK on amylase secretion was compared. There was no significant difference between Phe and Tyr treatments. 5. Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline 1 day before the collection of pancreatic amylase in Experiment 4. Both chicks showed increased amylase secretion with CCK (0.31 Crick unit), whereas the response was at a drastically reduced rate in chicks with the p-CP treatment.

摘要

在四项实验中研究了苯丙氨酸（Phe）对生长鸡胰腺淀粉酶分泌的影响。2. 在实验1中，通过翼静脉向鸡注射0.25毫升分别含0、0.1、0.5、2.5和12.5毫摩尔苯丙氨酸的生理盐水。各处理组之间的淀粉酶分泌未观察到显著差异。3. 在实验2中研究了不同浓度的苯丙氨酸与胆囊收缩素（CCK，0.31克里克单位）对淀粉酶分泌的影响。淀粉酶分泌随时间增加，尽管在苯丙氨酸处理中未检测到显著影响。4. 比较了苯丙氨酸和酪氨酸（Tyr）注射联合CCK对淀粉酶分泌的效果。苯丙氨酸和酪氨酸处理之间没有显著差异。5. 在实验4中，在收集胰腺淀粉酶前1天，给鸡腹腔注射苯丙氨酸羟化酶抑制剂dl - 对氯苯丙氨酸（p - CP）或生理盐水。两只鸡在注射CCK（0.31克里克单位）后淀粉酶分泌均增加，而p - CP处理的鸡的反应速率大幅降低。