Calişir Nermin, Bora Ibrahim, Irgil Emel, Boz Meral
Department of Neurology, Uludag University, School of Medicine, Bursa, Turkey.
Epilepsia. 2006 Oct;47(10):1691-9. doi: 10.1111/j.1528-1167.2006.00635.x.
The aim of this study was to determine the prevalence of epilepsy in the central district of Bursa, located in the western part of Turkey. The method used in this study was determined according to the recommendations of the World Health Organization (WHO) on prevalence research in developing countries.
In total, 2116 individuals were interviewed between September 1, 2004, and February 1, 2005. The sample group was selected from people living in the central district of Bursa, according to the stratified sampling method with regard to socioeconomic class, age, and sex. Neurology residents using standard questionnaires and semistructured interviews carried out face-to-face interviews.
Of the 199 presumptive cases detected in the initial interview, 26 (11 female, 15 male subjects) received the diagnosis of epilepsy on the day of assessment. Prevalence of active epilepsy was 8.5 per 1000, and lifetime prevalence was 12.2 per 1000 in the central district of Bursa. Classification of the epileptic seizures revealed that 30.7% of the patients had partial and 65.3% had generalized seizures; seizures could not be classified in 3.8%. The seizures had begun during the first decade of life in 50% of the cases, and 34.6% have been using regular medications.
Prevalence studies in our country are scarce; thus further research including different regions and multiple centers is needed. Addition of questions suitable to the Turkish social structure to the standard questions determined by WHO may be beneficial for practitioners in considering the diagnosis of epilepsy and referring these patients to specialized centers.
本研究旨在确定位于土耳其西部的布尔萨市中心区癫痫的患病率。本研究采用的方法是根据世界卫生组织(WHO)对发展中国家患病率研究的建议确定的。
2004年9月1日至2005年2月1日期间,共对2116人进行了访谈。样本组是根据社会经济阶层、年龄和性别的分层抽样方法,从居住在布尔萨市中心区的人群中选取的。神经科住院医师使用标准问卷和半结构化访谈进行面对面访谈。
在初次访谈中检测出的199例疑似病例中,有26例(11名女性,15名男性)在评估当天被诊断为癫痫。布尔萨市中心区活动性癫痫的患病率为每1000人中有8.5例,终生患病率为每1000人中有12.2例。癫痫发作的分类显示,30.7%的患者为部分性发作,65.3%的患者为全身性发作;3.8%的发作无法分类。50%的病例发作始于生命的第一个十年,34.6%的患者一直在使用常规药物。
我国的患病率研究较少;因此,需要开展包括不同地区和多个中心的进一步研究。在WHO确定的标准问题中增加适合土耳其社会结构的问题,可能有助于从业者考虑癫痫的诊断并将这些患者转诊至专科中心。