小干扰RNA的靶向递送
Targeted delivery of siRNA.
作者信息
Oliveira Sabrina, Storm Gert, Schiffelers Raymond M
机构信息
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
出版信息
J Biomed Biotechnol. 2006;2006(4):63675. doi: 10.1155/JBB/2006/63675.
Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies.
小干扰RNA（siRNA）的治疗应用需要将其递送至正确的细胞内位置，以便在负责病理的靶组织内与靶细胞内的RNA干扰机制相互作用。这些靶向水平中的每一个都构成了重大障碍。为了克服这些障碍，已经开发了几种策略，例如siRNA的化学修饰、病毒核酸递送系统和非病毒核酸递送系统。在此，我们讨论了为改善这些策略中每种策略在体内对siRNA的靶向递送所取得的进展。
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