Serletti Joseph M
Division of Plastic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Surg Oncol. 2006 Nov 1;94(6):532-7. doi: 10.1002/jso.20492.
Breast cancer is a ubiquitous disease affecting one in seven women. While breast conservation techniques are available for local control of the disease for many patients, not all patients are good candidates for these techniques. Mastectomy, therefore, remains a common method of breast cancer treatment. Methods of reconstruction include implant reconstruction and autogenous reconstruction. The advantages of autogenous reconstruction include the creation of a soft, ptotic breast mound, which tends to match a native contralateral breast both in and out of bra support. Autogenous reconstructions do not tend to change with time and usually do not require periodic revision as seen in implant reconstructions.
The most common method of autogenous reconstruction is the TRAM flap, either pedicled or free. The TRAM flap employs the redundant excess lower abdominal tissue typically removed during a cosmetic abdominoplasty. This tissue is brought to the mastectomy defect as a pedicled flap, passing subcutaneously from the upper abdomen and into the defect site. The pedicled flap is based upon the superior epigastric vessels. A free TRAM is harvested with the overlying muscle and the attached inferior epigastric vessels. This flap is completely separated from the abdomen and brought to the chest defect where it is anastomosed to either the thoracodorsal or internal mammary vessels. The donor defect within the abdominal wall is repaired with an inlay mesh with both the pedicled and free techniques.
Patient selection criteria usually help determine which technique is used. The advantage of the free flap technique is improved blood supply to the skin island. The free flap, therefore, is used in patients at higher risk for partial flap loss with the pedicled technique. Such high-risk patients include smokers, the obese, patients with significant medical comorbidities, and patients with prior abdominal surgery. Patients without these risk factors can be expected to achieve good results with either the pedicled or free flap technique.
Autogenous breast reconstruction with the TRAM flap achieves long lasting satisfactory results in most patients with the creation of a soft, naturally ptotic breast mound, which typically matches well a contralateral native breast.
乳腺癌是一种常见疾病,每七名女性中就有一人受其影响。虽然许多患者可采用保乳技术进行局部疾病控制,但并非所有患者都适合这些技术。因此,乳房切除术仍是乳腺癌治疗的常用方法。重建方法包括植入物重建和自体组织重建。自体组织重建的优点包括形成柔软、下垂的乳房隆起,无论有无胸罩支撑,其外观往往与对侧自然乳房相匹配。自体组织重建不会随时间变化,通常也不需要像植入物重建那样定期进行修复。
自体组织重建最常用的方法是横行腹直肌肌皮瓣(TRAM瓣),分为带蒂和游离两种。TRAM瓣利用了通常在腹壁整形术中切除的下腹部多余组织。该组织作为带蒂皮瓣转移至乳房切除缺损处,经皮下从腹部上方进入缺损部位。带蒂皮瓣以腹壁上血管为蒂。游离TRAM瓣则连同其上方的肌肉及附着的腹壁下血管一并切取。此皮瓣完全与腹部分离,转移至胸部缺损处,与胸背血管或胸廓内血管进行吻合。采用带蒂和游离技术时,腹壁的供区缺损均用补片进行修复。
患者选择标准通常有助于确定采用哪种技术。游离皮瓣技术的优点是皮瓣岛的血供更好。因此,游离皮瓣用于采用带蒂技术时皮瓣部分坏死风险较高的患者。这类高危患者包括吸烟者、肥胖者、有严重内科合并症的患者以及曾接受腹部手术的患者。没有这些危险因素的患者,采用带蒂或游离皮瓣技术都有望取得良好效果。
采用TRAM瓣进行自体乳房重建,在大多数患者中可获得持久满意的效果,形成柔软、自然下垂的乳房隆起,通常与对侧自然乳房匹配良好。