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采用自膨式支架植入术行缩窄成形术治疗成人主动脉缩窄

Coarctoplasty with self-expandable stent implantation for treatment of coarctation of aorta in adults.

作者信息

Haji-Zeinali Ali-Mohammad, Ghasemi Masuood

机构信息

Department of Cardiology, Tehran Heart Center, North Karegar and Jalal-Al-Ahmad Cross, Tehran, Iran.

出版信息

Arch Iran Med. 2006 Oct;9(4):348-53.

PMID:17061608
Abstract

BACKGROUND

Balloon angioplasty for treatment of coarctation of the aorta in adults, though promising, is sometimes limited by significant residual gradient (> 20 mmHg). Few studies have been reported on use of balloon-expandable stents in such a situation. We evaluated the use of self-expandable stents in patients with coarctation of the aorta.

METHODS

Eight hypertensive patients (age 15 to 27 years) with coarctation of the aorta (n = 6) or recoarctation (n = 2) and peak systolic gradient of > 40 mmHg underwent stent implantation. Balloon predilatation was done and self-expandable nitinol aortic stents (Optimed) were implanted in all patients.

RESULTS

The mean +/- SD peak systolic gradient decreased from a baseline of 55 +/- 15 (range: 40 - 75) to 5 +/- 2 (range: 3 - 7) mm Hg after angioplasty. Nitinol stents were easier to deploy and conformed better to aortic anatomy as compared with balloon-expandable stents. The mean +/- SD diameter of the coarcted segment increased from 3 +/- 1 mm to 16 +/- 2 mm. There were no complications in our series. On 6- to 9-month follow-up, all the implanted stents remained in their original positions and none showed evidence of fracture. Significant improvement in hypertension was seen in 7 out of 8 patients.

CONCLUSION

Stent implantation is safe and effective in treating coarctation of the aorta. Self-expandable stents were easy to implant, had good adaptation to the wall of the aorta, and in most patients had similar efficacy in reducing coarctation of the aorta as surgical repair.

摘要

背景

成人主动脉缩窄的球囊血管成形术虽前景可期,但有时会因显著的残余压差(>20 mmHg)而受限。关于在这种情况下使用球囊扩张支架的报道较少。我们评估了自膨胀支架在主动脉缩窄患者中的应用。

方法

8例高血压患者(年龄15至27岁),其中主动脉缩窄6例,再狭窄2例,收缩期峰值压差>40 mmHg,接受了支架植入术。所有患者均进行了球囊预扩张,并植入了自膨胀镍钛诺主动脉支架(Optimed)。

结果

血管成形术后,收缩期峰值压差的均值±标准差从基线的55±15(范围:40 - 75)降至5±2(范围:3 - 7)mmHg。与球囊扩张支架相比,镍钛诺支架更容易展开,且与主动脉解剖结构的贴合度更好。缩窄段的平均直径±标准差从3±1 mm增加到16±2 mm。我们的系列病例中无并发症发生。在6至9个月的随访中,所有植入的支架均保持在原位,且无骨折迹象。8例患者中有7例高血压得到显著改善。

结论

支架植入术治疗主动脉缩窄安全有效。自膨胀支架易于植入,对主动脉壁的适应性良好,且在大多数患者中,其在减轻主动脉缩窄方面的疗效与手术修复相似。

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