Kampen W U, Voth M, Pinkert J, Krause A
Clinic of Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Rheumatology (Oxford). 2007 Jan;46(1):16-24. doi: 10.1093/rheumatology/kel352. Epub 2006 Oct 25.
Radiosynoviorthesis (RSO) with an yttrium-90 colloid offers a local and minimally invasive therapy for treating inflammatory hypertrophy of the synovial membrane of the knee that has arisen from numerous kinds of disorder: these include rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthropathy, villonodular synovitis and others. There is substantial evidence that this treatment is efficacious and that, in view of the benefits that it offers, its tolerability and safety are very good. Administration should be restricted to patients in whom other therapies (including locally injected corticoids) have failed, and proper attention must be paid to correct administration, including post-treatment immobilization and the co-administration of corticoids, to minimize the risk of leakage and of efflux through the puncture channel.
用钇-90胶体进行放射性滑膜切除术（RSO）为治疗因多种病症引起的膝关节滑膜炎症性肥大提供了一种局部且微创的治疗方法：这些病症包括类风湿性关节炎（RA）、骨关节炎（OA）、脊柱关节病、绒毛结节性滑膜炎等。有大量证据表明这种治疗是有效的，并且鉴于其带来的益处，其耐受性和安全性非常好。给药应限于其他治疗方法（包括局部注射皮质类固醇）均无效的患者，并且必须适当注意正确给药，包括治疗后固定以及皮质类固醇的联合使用，以尽量减少渗漏和通过穿刺通道流出的风险。
