抗血管内皮生长因子疗法：结直肠癌治疗的新方法。

Anti-VEGF therapy: a new approach to colorectal cancer therapy.

作者信息

Carrato Alfredo, Gallego-Plazas Javier, Guillen-Ponce Carmen

机构信息

Medical Oncology Service, Elche University Hospital, Department of Medicine, Miguel Hernandez University, Camino de la Almazara 11, Elche, 03203 Alicante, Spain.

出版信息

Expert Rev Anticancer Ther. 2006 Oct;6(10):1385-96. doi: 10.1586/14737140.6.10.1385.

DOI:10.1586/14737140.6.10.1385

PMID:17069524

Abstract

The purpose of this review is to discuss the inhibition of vascular endothelial growth factor as a treatment for advanced colorectal cancer. The review will begin by summarizing the theory behind vascular endothelial growth factor inhibition and how this affects tumor angiogenesis. The major clinical trials that have examined antivascular endothelial growth factor agents to treat patients with advanced colorectal cancer will then be described. Finally, there is a commentary regarding the status of targeted agents currently in development for the treatment of advanced colorectal cancer and a discussion of the potential future considerations for the use of antivascular endothelial growth factor agents in clinical practice.

摘要

本综述的目的是讨论抑制血管内皮生长因子作为晚期结直肠癌的一种治疗方法。综述将首先概述血管内皮生长因子抑制背后的理论以及这如何影响肿瘤血管生成。接着将描述检验抗血管内皮生长因子药物治疗晚期结直肠癌患者的主要临床试验。最后，对目前正在研发用于治疗晚期结直肠癌的靶向药物的现状进行评论，并讨论在临床实践中使用抗血管内皮生长因子药物未来可能需要考虑的因素。