Malkesman O, Maayan R, Weizman A, Weller A
Interdisciplinary Program in Brain Sciences, Bar-Ilan University, Israel.
Behav Brain Res. 2006 Dec 15;175(2):408-14. doi: 10.1016/j.bbr.2006.09.017. Epub 2006 Oct 27.
In the current study we explored behavioral and endocrinological effects of exposure to social isolation during adulthood in two different genetic animal models of depression, the Flinders Sensitive Line (FSL), and their controls, Sprague-Dawley (SD) rats and the Wistar-Kyoto (WKY) strain and their controls, Wistar rats. Behavioral patterns of the different strains in coping with an intruder were studied in the "aggression" or resident-intruder test. We also measured basal plasma levels of the hypothalamic-pituitary-adrenal (HPA) axis hormones corticosterone and ACTH and their levels after chronic stress (isolation). Significant alterations in the levels of HPA hormones after social isolation were noted in the "depressed-like" strains. There were no significant behavioral differences between FSL and SD rats in the "aggression" test. In contrast, WKY rats exhibited less frequent aggressive-like and social behavior compared to Wistar controls. The results suggest that the FSL and WKY strains, both genetic animal models of depression, exhibit separate patterns of HPA axis modulation and aggressive-like behavior after social isolation. These different patterns may reflect two different types of depression. An "avoidant" or socially inhibited type of depressive-like behavior is seen most clearly in the WKY strain.
在当前研究中,我们在两种不同的抑郁症基因动物模型中探究了成年期遭受社会隔离的行为和内分泌影响,这两种模型分别是弗林德斯敏感系(FSL)大鼠及其对照斯普拉格-道利(SD)大鼠,以及Wistar-Kyoto(WKY)品系及其对照Wistar大鼠。在“攻击”或定居者-入侵者测试中研究了不同品系应对入侵者的行为模式。我们还测量了下丘脑-垂体-肾上腺(HPA)轴激素皮质酮和促肾上腺皮质激素的基础血浆水平及其在慢性应激(隔离)后的水平。在“类抑郁”品系中,社会隔离后HPA激素水平出现了显著变化。在“攻击”测试中,FSL大鼠和SD大鼠之间没有显著的行为差异。相比之下,与Wistar对照相比,WKY大鼠表现出较少的攻击样行为和社交行为。结果表明,FSL和WKY品系这两种抑郁症基因动物模型在社会隔离后表现出不同的HPA轴调节模式和攻击样行为模式。这些不同的模式可能反映了两种不同类型的抑郁症。“回避型”或社交抑制型的类抑郁行为在WKY品系中最为明显。