Duncan Erica J, Bollini Annie M, Lewison Barbara, Keyes Megan, Jovanovic Tanja, Gaytan Osvaldo, Egan Glenn, Szilagyi Sandor, Schwartz Marion, Parwani Arti, Chakravorty Subhajit, Rotrosen John
Atlanta Veterans Administration Medical Center, Decatur, GA, USA.
Psychiatry Res. 2006 Dec 7;145(2-3):137-45. doi: 10.1016/j.psychres.2006.04.006. Epub 2006 Oct 27.
Inhibition of the acoustic startle response by a smaller preliminary nonstartling stimulus is termed prepulse inhibition (PPI). Schizophrenia patients have impairments in PPI that may not fully normalize even when they are clinically stable on medication, particularly typical antipsychotics. There is evidence that more severe symptoms are associated with more severe PPI abnormalities, but the effect of antipsychotics on this relationship is not clear. Seventy-three male schizophrenia patients underwent acoustic startle and PPI testing. Symptom ratings were performed using the Brief Psychiatric Rating Scale (BPRS) and its subscales. Fifty-two subjects were treated with antipsychotic medication at time of testing; 21 were unmedicated. For all subjects, PPI was negatively correlated with the BPRS psychological discomfort subscale but not with BPRS total symptoms, BPRS positive symptoms or BPRS negative symptoms. For medicated subjects analyzed separately, there were no correlations with BPRS total scores or any subscales. For the unmedicated subjects analyzed separately, there were significant correlations of lower PPI with greater severity of BPRS total symptoms, positive symptoms and the psychological discomfort subscale. These data indicate that more severe symptoms are associated with lower PPI, but that medication status is an important factor in the relationship between symptom severity and sensorimotor gating.
较小的非惊吓性预刺激对听觉惊吓反应的抑制作用被称为预脉冲抑制（PPI）。精神分裂症患者存在PPI缺陷，即使他们在临床上通过药物（尤其是典型抗精神病药物）治疗达到稳定状态，这些缺陷也可能无法完全恢复正常。有证据表明，更严重的症状与更严重的PPI异常相关，但抗精神病药物对这种关系的影响尚不清楚。73名男性精神分裂症患者接受了听觉惊吓和PPI测试。使用简明精神病评定量表（BPRS）及其子量表进行症状评分。52名受试者在测试时接受了抗精神病药物治疗；21名未接受药物治疗。对于所有受试者，PPI与BPRS心理不适子量表呈负相关，但与BPRS总症状、BPRS阳性症状或BPRS阴性症状无关。对于单独分析的接受药物治疗的受试者，PPI与BPRS总分或任何子量表均无相关性。对于单独分析的未接受药物治疗的受试者，较低的PPI与更严重的BPRS总症状、阳性症状和心理不适子量表显著相关。这些数据表明，更严重的症状与更低的PPI相关，但药物治疗状态是症状严重程度与感觉运动门控之间关系的一个重要因素。
