长期护理机构中耐氟喹诺酮类的大肠杆菌
Fluoroquinolone-resistant Escherichia coli in the long-term care setting.
作者信息
Cohen Alana E, Lautenbach Ebbing, Morales Knashawn H, Linkin Darren R
机构信息
Columbia University, Department of Medicine, New York, NY, USA.
出版信息
Am J Med. 2006 Nov;119(11):958-63. doi: 10.1016/j.amjmed.2006.05.030.
BACKGROUND
Prior studies have found fluoroquinolone exposure to be a risk factor for infection with fluoroquinolone-resistant gram-negative rods in the acute care setting. However, risk factors may be different in the long-term care setting.
METHODS
A case-control study design was used to determine whether fluoroquinolone exposure is a risk factor for fluoroquinolone-resistant Escherichia coli urinary tract infections in a long-term care center. Cases had fluoroquinolone-resistant E. coli urinary tract infections; 4 controls were selected for each case.
RESULTS
Thirty-three case patients were eligible; 132 controls were then selected. In the multivariable analysis, fluoroquinolone-resistant E. coli urinary tract infection was more common with prior fluoroquinolone use (odds ratio 21.8, 95% confidence interval, 3.7-127.1).
CONCLUSIONS
Prior fluoroquinolone use is a strong risk factor for fluoroquinolone-resistant E. coli urinary tract infection in the long-term care setting. Further studies are needed to examine the effect of interventions to decrease fluoroquinolone-resistant infections in the long-term care setting, including studying the effect of decreasing fluoroquinolone use.
背景
先前的研究发现，在急性护理环境中，接触氟喹诺酮类药物是感染耐氟喹诺酮类革兰氏阴性杆菌的一个风险因素。然而，在长期护理环境中，风险因素可能有所不同。
方法
采用病例对照研究设计，以确定在一家长期护理中心，接触氟喹诺酮类药物是否是耐氟喹诺酮类大肠杆菌尿路感染的一个风险因素。病例组为耐氟喹诺酮类大肠杆菌尿路感染患者；为每个病例选择4名对照。
结果
33例病例患者符合条件；随后选择了132名对照。在多变量分析中，先前使用氟喹诺酮类药物的患者中，耐氟喹诺酮类大肠杆菌尿路感染更为常见（比值比21.8，95%置信区间，3.7-127.1）。
结论
在长期护理环境中，先前使用氟喹诺酮类药物是耐氟喹诺酮类大肠杆菌尿路感染的一个强烈风险因素。需要进一步研究，以检验在长期护理环境中减少耐氟喹诺酮类感染的干预措施的效果，包括研究减少氟喹诺酮类药物使用的效果。
Zotero 插件