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钠钾ATP酶:哺乳动物细胞膜上一种不可或缺的离子泵浦 - 信号传导机制

Na+, K+ -ATPase: an indispensable ion pumping-signaling mechanism across mammalian cell membranes.

作者信息

Jaitovich A Ariel, Bertorello Alejandro M

机构信息

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

出版信息

Semin Nephrol. 2006 Sep;26(5):386-92. doi: 10.1016/j.semnephrol.2006.07.002.

Abstract

Na(+), K(+)-adenosine triphosphatase is a ubiquitous enzyme present in higher eukaryotes responsible for the maintenance of ionic gradients across the plasma membrane. It creates appropriate conditions for critical cellular processes such as secondary transport of solutes and water, for pH regulation, and also for creating an electrical potential that gives singular qualities to excitable cells. It also served as a platform for a higher level of cellular complexity because many important signaling networks appear to be downstream events of the pump's function. Renal physiology and pathology are affected significantly by its presence, and it seems that both molecular and pharmacologic manipulations of its action can create different venues to deal with diverse disease states.

摘要

钠钾-腺苷三磷酸酶是一种存在于高等真核生物中的普遍存在的酶,负责维持跨质膜的离子梯度。它为关键的细胞过程创造了适宜条件,如溶质和水的继发性转运、pH调节,以及为可兴奋细胞赋予独特性质的电势的产生。它还作为细胞更高层次复杂性的一个平台,因为许多重要的信号网络似乎是该泵功能的下游事件。肾脏生理学和病理学受到其存在的显著影响,而且似乎对其作用进行分子和药理学操作都可以创造不同途径来应对多种疾病状态。

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