Gerhardt N, Schulz B S, Werckenthin C, Hartmann K
Department of Small Animal Medicine, Ludwig-Maximilians University Munich, Veterinärstrasse 13, 80539 Munich, Germany.
Vet Rec. 2006 Oct 28;159(18):591-4. doi: 10.1136/vr.159.18.591.
The concentrations of enrofloxacin were measured in the tears, saliva and serum of 14 cats with signs of upper respiratory tract infection and eight with no signs, after daily doses of 5 mg/kg. Enrofloxacin concentrations above the minimum inhibitory concentration of Chlamydophila felis were found in the saliva and tears of the cats with and without signs of upper respiratory tract infection. In a prospective randomised clinical trial, the efficacy of enrofloxacin against C. felis infection in cats with conjunctivitis was compared with the efficacy of doxycycline. Twenty-five cats were randomly assigned to treatment with either enrofloxacin or doxycycline for 14 days; 15 of the cats tested positive for C. felis by an immunofluorescent antibody test on conjunctival swabs. The two treatment groups showed equal improvements in the clinical signs of conjunctivitis and C. felis infection status; in each group three cats were still C. felis antigen-positive after the 14-day course of treatment, indicating a persistent infection. No side effects were observed in the cats treated with enrofloxacin.
对14只出现上呼吸道感染症状的猫和8只无感染症状的猫，每日按5mg/kg剂量给药后，检测其眼泪、唾液和血清中的恩诺沙星浓度。结果发现，无论有无上呼吸道感染症状，猫的唾液和眼泪中恩诺沙星浓度均高于猫衣原体的最低抑菌浓度。在一项前瞻性随机临床试验中，比较了恩诺沙星与强力霉素对患有结膜炎的猫感染猫衣原体的疗效。25只猫被随机分为两组，分别用恩诺沙星或强力霉素治疗14天；通过对结膜拭子进行免疫荧光抗体检测，其中15只猫的猫衣原体检测呈阳性。两个治疗组在结膜炎临床症状和猫衣原体感染状况方面的改善程度相同；每组中有3只猫在14天疗程结束后猫衣原体抗原仍为阳性，表明存在持续性感染。接受恩诺沙星治疗的猫未观察到副作用。
